Since diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world, the present investigation was carried out to explore anti-diabetic actions (α-amylase and α-glucosidase inhibitory potential ) of phytochemicals from Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC 50 value and the lowest IC 50 values were observed in PWE and DWE of SW. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts and these compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

W. A. N. M. Wariyapperuma, S. Kannangara, Y. S Wijayasinghe, S. Subramanium, B. M. Jayawardena 

PeerJ

Abstract :- https://peerj.com/articles/10070/