Setaria digitata, a nematode that lives in the peritoneal cavity of ruminants is the causative agent of cerebrospinal nematodiasis affecting livestock health. The ‘ACAT related enzyme 2 required for viability 1’ (arv-1) gene encodes putative lipid transporter that is essential in eukaryotes. The molecular characterization of nematode arv-1 has scarcely been studied and putative arv-1 isolated from S. digitata (Sd-arv- 1) was used for this purpose. This study revealed that Sd-ARV-1 is a structurally conserved, ubiquitously expressed protein, which may be involved in development, reproduction, tissue remodeling, muscle contraction etc., in nematodes. Therefore, the potential of Sd-ARV-1 as a target for the control of parasitic nematode diseases cannot be disregarded. 

Palliya Guruge Thilini Sithara Wickramatunga, Yasanthi Illika Nilmini Silva Gunawardene, Naduviladath Vishvanath Chandrasekharan & Ranil Samantha Dassanayake

Gene Reports 

Abstract:- https://doi.org/10.1016/j.genrep.2022.101643