This study assessed liver fibrosis by fibrosis-4 (FIB-4) score biomarker compared with transient elastography (TE) among a Sri Lankan transfusion-dependent beta-thalassaemia population using TE as the reference standard for liver fibrosis. With predefined cut-off values, the study estimated the sensitivity and specificity of the FIB-4 score as a screening tool to rule out significant liver fibrosis (F2). Receiver operating characteristics (ROC) curve analysis was carried out to estimate a new cut-off value with better sensitivity for the FIB-4 score for ruling in significant liver fibrosis (F-2). Regardless of the cut-off point, the FIB-4 score cannot be used as a good screening tool to pick up F2 in patients with TOT, irrespective Of their splenectomy Status.

Padmapani Padeniya , Dileepa Senajith Ediriweera, Arjuna P. De Silva, Madunil Anuk Niriella, Anuja Premawardhena

BMJ Open

Abstract:- http://dx.doi.org/10.1136/bmjopen-2022-061156