Chronic kidney disease of unknown etiology (CKDu) is an increasing global health issue and the exact risk factors are yet to be discovered. In our study, a computational approach was used to study the effects of pesticide and their metabolites on CKDu via investigating the interactions between vital renal enzymes and pesticides or metabolites. It was observed that some pesticides and metabolites bind at the active site or at regulatory sites of vital renal enzymes. Further, it was evident that some metabolites have higher binding interactions with considered renal enzymes compared to the parent pesticides. These findings shed light towards considering pesticide metabolites as a major risk factor towards CKDu. 

H. Rajapaksha, D. R. Pandithavidana and J. N. Dahanayake  

Biomolecules

Abstract :- https://doi.org/10.3390/biom11020261